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英夫利昔单抗内标(Infliximab Stable-Isotope Labeled Monoclonal Antibody )
产品简介:
英夫利昔单抗内标(Infliximab Stable-Isotope Labeled Monoclonal Antibody )
产品编号:CMS-MSQC9-100UG
产品规格:100ug
储存条件:-20度
价格:询价
性质
Related Categories | Antibody Characterization and Analysis, SILuMAb and SigmaMAb Antibody Standards for Mass Spec Analysis, 分子生物学, 生化试剂, 用于质谱分析的多肽及蛋白标准品, 蛋白质及衍生物, 蛋白质组学, 质谱 更多... |
recombinant | expressed in CHO cells |
antibody product type | primary antibodies |
assay | ≥90% (SDS-PAGE) |
packaging | vial of 100 μg |
shipped in | wet ice |
storage temp. | −20°C |
Preparation Note
Produced utilizing enriched media containing stable isotope labeled amino acids are 13C6, 15N4-labeled Arginine and 13C6, 15N2-labeled Lysine.
Infliximab Stable-Isotope Labeled Monoclonal Antibody is designed to be used as a internal standard for analysis of Infliximab in human serum.
Reconstitution
Infliximab recovery is maximized when 0.1% formic acid is used for reconstitution of the lyophilized product.Reconstitution with other solvents may reduce recovery. Do not freeze after reconstitution.
• Briefly centrifuge the vial at ~10,000 × g to collect the product at the bottom of the vial.
• Add 500 μL of ultrapure water containing 0.1% formic acid to the vial.
• Mix the contents by gently inverting the vial a minimum of 5 times.
• Allow the vial to stand at room temperature for at least 15 minutes and repeat mixing by inversion.
Physical form
Each vial of Infliximab Stable-Isotope Labeled Monoclonal Antibody contains the labeled antibody in a lyophilized form containing phosphate buffered saline.
Application
Poster: Quantification of Infliximab in Human Serum by LC-MS/MS Using A Full-Length Stable Isotope Labeled Internal Standard
General description
Infliximab Stable-Isotope Labeled Monoclonal Antibody (MSQC9) is a recombinant, stable isotope-labeled, monoclonal antibody which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in CHO cells, it is designed to be used as an internal standard for the quantitative mass spectrometry analysis of Infliximab in human serum. Infliximab is a chimeric monoclonal antibody biologic drug that works against tumor necrosis factor alpha (TNF-a) and is used to treat autoimmune diseases.
Infliximab has been approved for the treatment of Crohn′s disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis.Infliximab Stable-Isotope Labeled Monoclonal Antibody is for research use only and is not intended for diagnostic or therapeutic use.
Peptide | z (Q1) | Q1 m/z | Q3 m/z | Fragment ion type | Dwell (ms) | DP | CE |
DILLTQSPAILSVSPGER | 2 | 948.525 | 1125.626 | y11 | 50 | 100.3 | 43.0 |
DILLTQSPAILSVSPGER | 2 | 948.525 | 731.368 | y7 | 50 | 100.3 | 43.0 |
DILLTQSPAILSVSPGER | 2 | 948.525 | 458.236 | y4 | 50 | 100.3 | 43.0 |
DILLTQSPAILSVSPGE[R] | 2 | 953.530 | 1135.635 | y11 | 50 | 100.3 | 43.0 |
DILLTQSPAILSVSPGE[R] | 2 | 953.530 | 741.377 | y7 | 50 | 100.3 | 43.0 |
DILLTQSPAILSVSPGE[R] | 2 | 953.530 | 468.244 | y4 | 50 | 100.3 | 43.0 |
YASESMSGIPSR | 2 | 642.798 | 1050.488 | y10 | 50 | 78.0 | 32.0 |
YASESMSGIPSR | 2 | 642.798 | 747.382 | y7 | 50 | 78.0 | 32.0 |
YASESMSGIPSR | 2 | 642.798 | 616.341 | y6 | 50 | 78.0 | 32.0 |
YASESMSGIPS[R] | 2 | 647.802 | 1060.497 | y10 | 50 | 78.0 | 32.0 |
YASESMSGIPS[R] | 2 | 647.802 | 757.390 | y7 | 50 | 78.0 | 32.0 |
YASESMSGIPS[R] | 2 | 647.802 | 626.350 | y6 | 50 | 78.0 | 32.0 |
GLEWVAEIR | 2 | 536.793 | 773.430 | y6 | 50 | 70.2 | 28.2 |
GLEWVAEIR | 2 | 536.793 | 587.351 | y5 | 50 | 70.2 | 28.2 |
GLEWVAEIR | 2 | 536.793 | 488.283 | y4 | 50 | 70.2 | 28.2 |
GLEWVAEI[R] | 2 | 541.797 | 783.439 | y6 | 50 | 70.2 | 28.2 |
GLEWVAEI[R] | 2 | 541.797 | 597.359 | y5 | 50 | 70.2 | 28.2 |
GLEWVAEI[R] | 2 | 541.797 | 498.291 | y4 | 50 | 70.2 | 28.2 |
SINSATHYAESVK | 2 | 703.849 | 1092.532 | y10 | 50 | 82.4 | 34.2 |
SINSATHYAESVK | 2 | 703.849 | 833.415 | y7 | 50 | 82.4 | 34.2 |
SINSATHYAESVK | 3 | 469.569 | 603.791 | y11+2 | 50 | 65.3 | 23.1 |
SINSATHYAESV[K] | 2 | 707.856 | 1100.546 | y10 | 50 | 82.4 | 34.2 |
SINSATHYAESV[K] | 2 | 707.856 | 841.429 | y7 | 50 | 82.4 | 34.2 |
SINSATHYAESV[K] | 3 | 472.240 | 607.798 | y11+2 | 50 | 65.3 | 23.1 |
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邮 箱: zhihong.xiao@cmass.com.cn
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